Formula: C₅₁H₈₄N₁₆O₂₁
Molecular Weight: ~1257 Da (1257.31 g/mol)
Sequence: {Glp}-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser)
Synonyms: Cibinetide, EPO-derived peptide
Key Functions & Effects
Activates Innate Repair Receptor (IRR):
It binds to the IRR (a complex of EPO receptor and CD131) to trigger tissue protection.
Reduces Neuropathic Pain:
Effectively alleviates pain in nerve damage, even targeting TRPV1 channels, and suppresses spinal inflammation.
Improves Metabolic Control:
Shows benefits in Type 2 Diabetes by improving HbA1c and lipid profiles.
Promotes Nerve Repair:
Increases corneal nerve fiber density (CNFD) in some diabetic patients, indicating nerve regeneration.
Non-Hematopoietic:
Unlike EPO, it doesn't stimulate red blood cell production, avoiding associated side effects like hypertension.
How it Works
ARA 290 separates the beneficial, tissue-protective functions of EPO from its hematopoietic (blood-building) effects by selectively activating the IRR, leading to anti-inflammatory and regenerative signals.
Formula: C₅₁H₈₄N₁₆O₂₁
Molecular Weight: ~1257 Da (1257.31 g/mol)
Sequence: {Glp}-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser)
Synonyms: Cibinetide, EPO-derived peptide
Key Functions & Effects
Activates Innate Repair Receptor (IRR):
It binds to the IRR (a complex of EPO receptor and CD131) to trigger tissue protection.
Reduces Neuropathic Pain:
Effectively alleviates pain in nerve damage, even targeting TRPV1 channels, and suppresses spinal inflammation.
Improves Metabolic Control:
Shows benefits in Type 2 Diabetes by improving HbA1c and lipid profiles.
Promotes Nerve Repair:
Increases corneal nerve fiber density (CNFD) in some diabetic patients, indicating nerve regeneration.
Non-Hematopoietic:
Unlike EPO, it doesn't stimulate red blood cell production, avoiding associated side effects like hypertension.
How it Works
ARA 290 separates the beneficial, tissue-protective functions of EPO from its hematopoietic (blood-building) effects by selectively activating the IRR, leading to anti-inflammatory and regenerative signals.
For laboratory research use only.
Not intended for human consumption or therapeutic use.
Handling by trained research professionals is required.
